The immune-system protects the organism from agression by pathogens and cancer. Immune-responses need to be carefully controlled to adapt to the type of agression and to avoid "immune-pathology" such as autoimmune disease (e.g. type I diabetes, rheumatoid arthritis), allergy (e.g. asthma), and chronic inflammation (e.g. inflammatory bowel diseases).  Our research-team works on the molecular and cellular mechanisms involved
NEWS
Romain Torres, B.Sc., has obtained a doctoral fellowship from the French ministry of research and education and will work on ageing of the immune system under supervision of Dr. Olivier Joffre. Welcome to our team Romain !
In October 2022, Dr. Benoit Salomon will join our team. Benoit works on the role of metabolism, co-stimulatory/co-inhibitory signals and TNF family cytokines in regulatory T cell-biology and novel markers of these cells in the control of autoimmune diseases and cancer. Welcome to the team Benoit !
OUR RESEARCH TOPICS

Development of immune-tolerance

Immune-tolerance mainly develops in the thymus. We investigate the molecular and cellular mechanisms involved

Our epigenetic studies

The development and function of immune- cells are controlled by epigenetic mechanisms, which we investigate

Control of regulatory T cells

The suppressive function of Tregs needs to be carefully controlled.  We study the molecular mechanisms involved